The most famous exchange starts at 8:46. Language NSFW
Most of the people on screen in this episode have gotten in trouble in real life in one way or another: the late Garry Shandling was wiretapped by Anthony Pellicano at the behest of mogul Brad Grey when he sued Grey, his business partner; also, Garry was sued by Linda Doucett, who preceded Scott Thompson as Hank’s on-screen assistant, for palimony and for firing her when she broke up with Garry; Rip Torn drove into the lobby of a bank under the mistaken impression that it was his driveway; Jeffrey Tambor is currently being fired from starring in Transparent on charges of not being transphobic enough; Sarah Silverman’s patriotism is currently being called in question; Wallace Langham pled no contest to punching out a gay paparazzi “who had allegedly made accusations against Langham’s girlfriend’s tattoos” (I don’t know what that means); Langham replaced Jeremy Piven on the show, who is a rare figure in Weinsteingate in denying everything. I haven’t heard any good gossip about Mary Lynn Rajskub or the late Bruno Kirby, but I’m probably not looking hard enough.
In summary, professional-level funny people tend to get themselves into sticky situations now and then not unlike the ones their characters get into on-screen.
But, damn, were they funny together.